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Who Should Use Caution and When to Contact Your Provider Patients with a personal history of pancreatitis, medullary thyroid cancer, multiple endocrine neoplasia type 2, or severe dehydration should avoid GLP-1 therapy or use it only under close specialist supervision

A meal heavy in fat or fiber takes 4 to 6 hours to digest even without tirzepatide, and once the drug begins slowing gastric emptying after injection, that meal could sit for 8 to 10 hours

The pentose phosphate pathway fulfills two important cellular requirements

As clinicians at Mass General Brigham have pointed out, every weight loss method causes some lean mass loss, not just GLP-1 medications