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When GLP-1 drugs may be appropriate for lipoedema With all of the above said, there are circumstances where GLP-1 drugs may be a reasonable consideration for women with lipoedema: When prediabetes or type 2 diabetes is present and not adequately controlled through nutrition alone When chronic stress and cortisol dysregulation are significantly impairing metabolic function and the ability to lose abdominal weight, despite a well-structured nutrition protocol When these decisions are made collaboratively with a medical team that understands lipoedema and is actively monitoring muscle mass, bone health, nutritional status, and mental health In all cases, a low-inflammatory, nutritionally balanced eating approach remains essential alongside the medication: GLP-1 drugs are not a replacement for good nutrition

Retatrutide was optimized to maximize brown adipose activity without net glycemic disturbance, thanks to the combined glucose-normalizing effect of the GLP-1/GIP incretins

There's a supplement called Mirica, M-I-R-I-C-A

available over-the-counter (Alli 60 mg) or on prescription (Xenical 120 mg)