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The triple mechanism suggests that discontinuation effects could be even more pronounced than with tirzepatide
However, this treatment paradigm demonstrates the acute reduction in apoB48 concentrations in the TRL fraction for 10 h post-injection (37%) compared to placebo controls with a significant decrease in apoB48 production rate, no change in fractional catabolic rate, and no changes in hepatic apoB100 levels were observed (Xiao et al., 2012)
Steady-state drug exposure is not achieved for several additional weeks after that, meaning the full pharmacological effect requires roughly 20-24 weeks to manifest
But as a neuroscience Ph.D
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