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Animal data suggest subcutaneous routes required substantially higher doses than intravenous in rabbits, 1 mg/kg subcutaneous versus 25 mcg/kg IV, a 40-fold difference

Another commenter stated that for products cleared via the 510(k) pathway that are classified as gels, liquids, or particulates, reimbursement should follow the existing DME pathway, as these products are not skin substitutes and should not be reimbursed under the skin substitute payment framework

The exact amount depends on the concentration of the solution and the volume injected

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