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Repurposing beta-3 adrenergic receptor agonists for Alzheimers disease: Beneficial effects in a mouse model

Calcium ionophore A23187 and the protein kinase C activator phorbol myristate acetate (PMA) were used as positive control for validation of NFAT-RE-mediated transcriptional activities

On the one hand, ferroptotic tumor cells release damage-associated molecular patterns (DAMPs) such as high-mobility group protein B1 (HMGB1) and ATP, which enhance the tumor-killing effect of CD8+ T cells by activating dendritic cells and promoting antigen presentation ( 3 Radiation-induced ferroptosis The hallmarks of ferroptosis are the accumulation of ROS, lipid peroxidation, and a decrease in GSH levels