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as a result, surfactant production decreases markedly, which in turn causes alveolar fluid accumulation leading to alveolar collapse and ARDS (Matthay and Zemans, 2011

For instance, 520-nm Poly(lactic-co-glycolic acid) nanoparticles can be detected in neuronal bundles after intranasal administration, indicating their transcellular neuronal transport, whereas 80-nm and 175-nm particles were only detected in other cell types, albeit with a more rapid distribution [49]

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