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Adherence is significantly lower among those using GLP-1s for weight loss versus those using them to manage type 2 diabetes one study found that about 65% of patients without type 2 diabetes discontinued GLP-1 therapy within one year, compared to 47% of patients with type 2 diabetes

All discussions must be framed within the context of preclinical research and anecdotal reports from the scientific community

This leads to the formation of damage that is more persistent and harmful than in the case of glycation or oxidation reactions alone

This leaves late-comers Roche, AstraZeneca, Novartis, Pfizer, Amgen and smaller player Viking with a fraction of the market, approximately $20B