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In the SURMOUNT-1 trial, tirzepatide at the highest dose (15 mg) produced average weight loss of 22.5% versus approximately 15% for semaglutide in comparable trials

Retatrutide has a broader mechanism and very promising early results, which explains why it is attracting so much attention

At 6 months, patients who discontinued treatment within 0-3 months had a -1.8% weight change, while those persistent for 12 months saw an -8.1% change

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