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doi: 10.1126/science.1254257 20 LeeSBFrattiniVBansalMCastanoAMShermanDHutchinsonKet al

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For women, weight loss tends to be a little slower-going than it is for men

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The principal regulator of glutamine utilization is the transcription factor c-myc , which is often upregulated in proliferating cells [17,18]

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Key programs include STEP (14.9% weight loss at 68 weeks in STEP 1), SELECT (20% MACE reduction in 17,604 patients), SUSTAIN (HbA1c reductions up to 2.2%), and PIONEER (oral formulation validation)

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