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Excessive excitatory neurotransmitter glutamate is released in the synaptic cleft, glutamate receptors are over-activated, and Ca 2+ flows into neurons, triggering ion homeostasis imbalance, oxidative stress, and mitochondrial dysfunction

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These findings suggest that the automated verification system successfully balances two crucial objectives: controlling off-label or not-covered utilization while maintaining timely access for patients with a documented medical need