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However, excessive or impaired angiogenesis, even if initially compensatory, can become pathological, exacerbating neurodegenerative processes by increasing vascular instability and inflammation (Sweeney et al

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Also, in the case of 3D cultures, Western blotting analysis demonstrated that angiotensin-converting enzyme and CD40 were upregulated, and that sirtuin 1 and sirtuin 6 were inhibited after TNF- treatment

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