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Experimental and animal studies demonstrated that the downstream products of vitamin B12 metabolism are increased and oxidative stress, steatosis, and fibrosis develop in the liver in cystathionine -synthase-deficient mice (57)

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In the past few decades, many studies have shown that berberine and palmatine and their derivatives have anti-inflammatory, bacteriostatic, and mucosal protection activities in the digestive system [58,59]

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