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The cuticle forms the outermost covering of an insects integument, which consists of a single cell layer ( Antimicrobial peptides (AMPs) are produced as a part of humoral immune mechanism ( Drosophila melanogaster larvae, after an infection illustrates the significance of hemocytes ( Drosophila are more vulnerable to microbial infections after having their phagocytic hemocytes eliminated either genetically or mechanically ( Once the hemocoel is infected, cellular immune responses begin almost immediately, while humoral immune responses take many hours to begin ( Drosophila ( Bacillus subtilis , Escherichia coli and most notably Staphylococcus aureus ( Subsequently, after infections, pathogens developed strategies to avoid the host immune reaction, which may have enabled insects advance the sophistication of their immune response systems ( Supplementary File ), most of the studies were published in research and review papers, and journals like journal of biological chemistry and developmental and comparative immunology were the forerunners in the insect immunity related papers

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