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These are all slow approaches because they use one ingredient in a low concentration, slow absorbing base that needs daily use over weeks to accumulate a visible effect

Another RCT examined the effect of B1 (300 mg/d), B6 (80 mg/d), B9 (2mg/d), B12 (500 g/d) supplements and B-complex for 12 weeks on patients with migraine, compared with the placebo