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NAPQI is neurotoxic : Crosses the placenta, depletes fetal brain glutathione, generates oxidative stress, and triggers cell death in neural tissue at doses below those causing maternal liver toxicity

Key interaction considerations: Stimulant-containing supplements (including those with caffeine, synephrine, or yohimbine) should be avoided by people taking monoamine oxidase inhibitors (MAOIs) or with uncontrolled hypertension

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In a landmark RCT, 174 patients with SAH were randomized to receive prednisolone with intravenous (IV) NAC (85 patients) for 5 days or prednisolone with IV 5% glucose solution (89 patients) [54]