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The neurons in these areas that express the GLP-1 receptor interact with GLP-1 analogs, indirectly influencing central circuits

254,255 High-fat diet-fed mice treated with exendin-4 (a hormone found in the saliva of the Gila monster which is synthetically modified to produce exenatide for T2D treatment) had decreased mRNA levels of the pro-inflammatory cytokines tumour necrosis factor-alpha, monocyte chemoattractant protein 1 and signal transducer and activator of transcription 3

Adults with a BMI of 30 or higher are medically classified as obese and often qualify for treatment

However, there are still many controversies regarding the tolerability and adverse reactions of GLP-1RAs in the treatment of diabetes