glp-1 endurance athletes Can Medications Affect Athletic Performance and Recovery? SHOULD ENDURANCE ATHLETES USE GLP-1s?

Metabolism 52 , 699704 (2003)

The current work is predicated on previous suggestions that GLP-1 activity depends on adoption of a reverse turn near the peptide N-terminus, which raises the possibility that the N-terminal helical conformation in the cryo-EM structure of receptor-bound GLP-1 12 may not fully capture structural requirements for signaling

[12] The majority of states follow the Learned Intermediary Doctrine in some form

Interestingly, this effect seems to be mediated through hepatic glucagon signalling, as infusion into the portal vein induced a satiating response whereas infusion into the inferior vena cava did not (64)