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Here we investigated the effect of allyl-isothiocyanate (AITC) on Arabidopsis thaliana mutants impaired in homeostasis of the low-molecular weight thiol glutathione
Elevated phosphate activates RUNX2 in VSMCs, promoting calcium-phosphate deposition and arterial stiffening ( Figure 1 delineates the dysregulated mineral metabolism axis in CKD, wherein FGF-23 induces parathyroid hyperplasia and downregulates calcium-sensing receptors (CaSR), abrogating calcium-mediated suppression of PTH secretion ( FIGURE 1 3 CKD-associated immune dysregulation 3.1 Chronic inflammation and oxidative stress Chronic kidney disease is marked by a persistent state of low-grade inflammation, a critical factor driving disease progression and its associated complications, such as cardiovascular disease (CVD) ( Oxidative stress, another defining feature of CKD, significantly amplifies this inflammatory milieu and impairs immune function
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