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Apart from food intake, oral glucose administration induces GIP and GLP-1 secretion dependently on the intestine-specific glucose transporters sodium glucose cotransporter-1 (SGLT1) and glucose transporter 2 (GLUT2) (37, 38)

The result is a synergistic GH secretion profile that neither compound achieves in isolation, combining GHRH-receptor-driven cAMP/PKA somatotroph amplification with GHS-R1a-mediated intracellular calcium mobilisation for a physiologically pulsatile, dual-pathway GH response

doi: 10.1007/s00726-020-02835-2