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Response to GLP-1RA was initially assessed by comparing the response to treatment of 1,119 participants with T2D treated with GLP-1RA in a meta-analysis of the three similar cohorts Innovative Medicines Initiative DIabetes REsearCH on patient straTification (IMI-DIRECT) [29], Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) [30] and Predicting Response to Incretin Based Agents (PRIBA) [31] and replication was sought in the methodologically different GSK-HARMONY Trial [32] and the EXSCEL Trial [33]

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After the run-in period on pioglitazone monotherapy, patients with inadequate glycemic control (A1C 7% to 10%) were randomized to the addition of either 100 mg of JANUVIA or placebo, administered once daily