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Accordingly, in experimental models, supplements of omega-3 PUFAs have been demonstrated to exert neuro-protective and cardio-protective effects against hypothyroidism-induced damage, while attenuating hyperthyroidism-associated complications, including arrhythmias and hepatic dysfunction, thereby conferring protective actions on peripheral tissues across opposing states of thyroid dysfunction [127,130,131,132]

C., Chaumontet, J., Vande Voorde, R

GPX4 catalyzes the reduction of hydrogen peroxide, organic hydroperoxides, and lipid peroxides at the expense of reduced glutathione and functions in the protection of cells against oxidative stress

Furthermore, S-nitrosylation of specific targets can either promote (e.g., inhibiting GPX4) or inhibit (e.g., activating survival pathways) ferroptosis