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For instance, HUVECs were cultured with high glucose levels (30 mmol/L) for short-term (48 h and 72 h) and long-term exposures (13 days) [182], and both exposure times consistently induced cell apoptosis, showing approximately a 20% increase after 48 h and around a 46% increase after long-term exposure

That changed when the FDA began increasing enforcement against non-FDA-approved compounded GLP-1 products in February 2026, citing safety concerns

AANAT, arylalkylamine N-acetyltransferase

The most prevalent factors employers take into consideration for GLP-1 drug coverage for obesity care include: Obesity as a risk factor for chronic conditions and associated costs67% Drug shortages47% Impact/effectiveness of cost-control mechanisms47% Existing coverage through government programs40% Long-term costs33% Patient and prescriber demand33%