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Advice for Healthcare Professionals The MHRA has advised that healthcare professionals remain vigilant for symptoms of acute pancreatitis, which may be challenging to recognise in early stages, and use GLP-1/GIP receptor agonists and GLP-1RAs with caution in patients with a history of pancreatitis
An observational study of a cohort of 12 241 adults in the United States also used liver enzymes as a marker of MASLD and reported that MASLD (defined by elevated ALT, aspartate aminotransferase, or gamma-glutamyl transferase without evidence of an alternative explanation) was significantly less common in postmenopausal women using HRT compared to those not using HRT (OR 0.69
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