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In late 2025, Novo Nordisk received approval in the US for a once-daily oral version of semaglutide, under the brand names Wegovy for weight loss and Rybelsus for diabetes [21]

In Glp1r OB-hM3Dq WD-maintained mice, CNO injection decreased intake of both chow and high-fat high-sugar diets during refeeding tests (Figs

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