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WEDNESDAY, July 23, 2025 (HealthDay News) -- Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are associated with reduced type 2 diabetes mellitus (T2DM)-related dementia risk compared with metformin, according to a study published online July 22 in BMJ Open Diabetes Research & Care.Mingyang Sun, from the People's Hospital of Zhengzhou University in China, and colleagues conducted a retrospective cohort study using data from a global health research network between 2004 and 2024 to examine the comparative effectiveness of GLP-1 RAs and metformin in reducing dementia risk

In late 2025, the FDA approved an oral semaglutide formulation (Wegovy oral) for weight management at 25mg and 50mg doses, with clinical trials showing 13-14% body weight reduction

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The injectable preparation is formulated as the highly water-soluble sodium-phosphate ester, enabling rapid systemic distribution after intravenous (IV) or intramuscular (IM) administration