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During the first week of Semaglutide GLP-1 treatment, you may notice a reduction in appetite and improvements in blood sugar levels, though mild side effects like nausea or fatigue are common initially

Therefore, more extensive randomized controlled trials (RCTs) are essential to elucidate these relationships and inform clinical practice

The main finding of our study is the observation that a degree of renal impairment affects the magnitude of the effect of liraglutide on blood pressure and natriuresis