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These medications are part of a buzzy class of appetite-suppressing drugs called GLP-1s that include Ozempic and Wegovy, which have come to mainstream attention over the past year

Mention semaglutide use directly, since many primary care clinicians are less familiar with GLP-1-associated iron depletion than with other medication side effects

They influence neuronal signaling (e.g., via the vagus nerve and the enteric nervous system), hormonal responses (such as modulation of cortisol and the HPA axis) and immune activity (including cytokine regulation and inflammation

Microdosing is about fine-tuning GLP-1 signaling, not overpowering it