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CagriSema (semaglutide + cagrilintide), filed by Novo Nordisk in December 2025, achieved 22.7% weight loss in trials and could receive FDA approval in 2026

However, a small proportion of patients discontinue Ozempic specifically due to gastrointestinal adverse events that do not resolve with conservative management

Blood thinners Meloxicam can increase the risk of bleeding when taken with blood-thinning drugs like antiplatelets and anticoagulants, which are often used to prevent stroke and heart attacks or treat blood clots

Caution should be taken with those that have megaloblastic anemia as B12 can reduce potassium levels in the blood