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Trimethylamine N-oxide promotes oxidative stress and lipid accumulation in macrophage foam cells via the Nrf2/ABCA1 pathway

Details of treatment administration are provided in the ESM Methods

The company expects this pricing change to have only a "low single digit" negative impact on its 2026 global sales growth, with semaglutide sales still projected to rise from $33 billion in 2025 to roughly $36 billion in 2026

Pseudopunicic acid B improves high-fat diet-induced MAFLD by significantly downregulating gut flora positively correlated with liver injury and enriching tryptophan metabolic pathways, elevating the level of its microbial metabolite cinnamic acid