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These alterations in the composition or quantity of the NFB dimer have been found to alter downstream target gene expression, contributing, in some cells, to increased expression of pro-inflammatory genes and a pro-apoptotic environment (170, 197, 275)

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Adalimumab, the first recombinant synthetic fully human TNF monoclonal antibody approved for marketing, has gained global approval for treating a range of conditions, including RA, AS, psoriasis, and various other diseases