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Tilting the redox balance towards oxidative stress in nucleated cells, i.e., by increasing the ROS levels, normally leads to cell death (apoptosis) or to an acceleration in ageing [111]

Decreased GSH levels and impaired GSH synthesis and recycling have been observed in aging, suggesting a potential therapeutic target for restoring redox balance and mitigating oxidative damage

In both cases, regular, consistent use within an appropriate routine is the practical takeaway, not a precise clock time

They may be considered as part of dual or triple therapy when specific criteria are met, including BMI thresholds (35 kg/m or 32.5 kg/m in certain ethnic groups) and when weight loss would benefit other obesity-related comorbidities