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Drugs fitting this profile (like TB-500) typically require high, sustained plasma concentrations to maintain a significant level of receptor or binding site saturation

95 : 212221 Horsten M, Wamala SP, Vingerhoets A, Orth-Gomer K

doi: 10.1016/j.cmet.2019.06.005 103

Previous studies have reported that putrescine can upregulate phenylalanine ammonia-lyase (PAL), the rate-limiting enzyme in phenylpropanoid biosynthesis, and inhibit polyphenol oxidase (PPO), which may contribute to enhanced phenolic and flavonoid accumulation 18,49,50,51,52