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However, notably in a PCP model of schizophrenia, only 30 mg/kg, but not 3 or 10 mg/kg, rescued defects in hyperlocomotion and PPI, in stark contrast to cell culture models where lower models were more beneficial (Shirai et al., 2012)

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All the procedures involving the animals and their care were conformed to the institutional guidelines, in compliance with national and international laws and guidelines for the use of animals in biomedical research and housed in pathogen-free conditions

Given the consistent effects across sexes, our subsequent investigations focused on male rodents to identify potential brain regions mediating tirzepatides effects on alcohol-related responses