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Systemic effects less commonly include mild dizziness or lightheadedness (may be copper-related), temporary nausea or headache (typically resolves within hours), mild fatigue (rare, reported with higher doses), and transient flu-like symptoms (very rare, may relate to systemic inflammatory response)

Vitamin B12 helps make red blood cells and keeps the nervous system healthy

In contrast to -glutamylcysteine synthetase, glutathione synthetase accepts a large variety of glutamyl-modified analogs of -glutamylcysteine, but is much more specific for cysteine-modified analogs of -glutamylcysteine

It is followed by the partitioning into the sebum followed by the diffusion through the lipids