Beside the oxidative stress response, multiple genes related to copper defense that were found in both genomes, such as copC and copZ are assumed to be upregulated during copper stress, as well as active copper transport (Teitzel et al., 2006)
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Similarly, studies evaluating the efficacy of DA treatment of PRL-secreting PAs in the male population only, have shown similar effects to that described above in the general population, regardless of initial tumor size ( The clinical response is highly variable