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Another rare but serious risk is pancreatitis, which presents as severe abdominal pain, sometimes radiating to the back, and may be accompanied by nausea and vomiting

Geldanamycin confers fungicidal properties to azole by triggering the activation of succinate dehydrogenase

If these symptoms are left uncontrolled and/or untreated, diabetes progresses to more severe complications including cardiovascular disease, neuropathy, nephropathy, retinopathy, and chronic ulceration [4]

For instance, it may affect the metabolism of drugs that are substrates of the cytochrome P450 enzyme system, potentially altering their efficacy or toxicity