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In conclusion, the results of the current study allow to speculate that l-ARG might represent a potential alternative for patients with mildmoderate vasculogenic ED with contraindication to PDE5i or who had experienced adverse effects upon PDE5i treatment and might require a different therapeutic approach, or, in association to lower PDE5i doses, to reduce the occurrence and severity of PDE5i-associated adverse effects meanwhile potentially exerting an additive or synergistic effect

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