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Injectable semaglutide (Ozempic, Wegovy) requires refrigeration before first use Ozempic can be stored at room temperature after opening for 56 days Wegovy can be stored in the original carton at 46 F to 86 F for 28 days if needed Oral semaglutide (Rybelsus) does not need refrigeration and should be stored at room temperature in a dry place Ozempic storage guidelines Below are the storage guidelines for Ozempic: Store unopened pens in the refrigerator at 36F to 46F (2C to 8C) After first use, you can keep Ozempic at room temperature (59F to 86F) for up to 56 days You can also continue refrigerating after opening for the same 56-day period Always keep the pen cap on when not in use Never freeze the medication Wegovy storage guidelines Below are the storage guidelines for Wegovy: Refrigerate unopened pens at 36F to 46F (2C to 8C) Wegovy can be stored in the original carton at 46 F to 86 F (8 C to 30 C) for up to 28 days before removing the pen cap Store in the original carton and packaging to protect from direct sunlight and excessive heat Do not freeze the medication Both injectable forms should be stored away from the cooling element in your refrigerator and kept upright whenever possible

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"Semaglutide stays in the system for around 5 weeks after your last dose," notes Gia Eapen, MD

This hormone helps regulate appetite and blood sugar levels