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Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program

Skin reactions or injection site effects may occur with B12 supplementation but are not caused by elevated serum levels

Unknown long-term effects : There is no long-term safety data for either compound used individually in the general population, let alone in combination