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Diarrhea is a common gastrointestinal side effect of semaglutide, especially as the medication alters how quickly food moves through the digestive system

For nausea, patients should be advised to: Eat smaller, more frequent meals rather than three large meals Avoid lying down immediately after eating Choose bland, low-fat foods when symptoms are present Stay well-hydrated with clear fluids between meals Consider ginger tea or other non-pharmacological remedies If gastrointestinal side effects are intolerable, the prescribing physician may recommend extending the titration period, holding at the current dose, or stepping back to a lower dose temporarily

For drug-refractory patients who are eligible for a device, a trial of GES may be considered