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Early studies in vascular patients concluded that heterozygosity for the mutations T833C and G919A of the CBS gene was associated with an abnormal response to a methionine load, which was caused by the heterozygosity (Boers, 1997b

Patients with a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2) should avoid these medications due to the potential risk of thyroid C-cell tumors

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Laboratories often adopt aliquoting strategies that reduce repeated vial openings and reduce contamination risk, and they track the number of handling events for each batch used in a study