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Notably, Nrf2 provides an antioxidant response that is activated with both hyperglycemia endothelial cell in vitro models and an in vivo high fat diet mouse model (Ungvari et al., 2011)

Crucially, the GSH/Glutaredoxin 1 system maintains the reduced state of cysteine residues within the copper-binding motifs of the transporters ATP7A and ATP7B, which is essential for their copper-transport activity [108]