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Heterogeneity in the analyses vs active comparators could be attributed to differences in efficacy between the two GLP-1 RAs comparators (dulaglutide and semaglutide) or to differences in background glucose-lowering therapy between the two trials with basal insulin

The most commonly observed side effects in controlled clinical studies, 5% or greater and at least 1.5 times placebo, in adults include paraesthesia, dizziness, dysgeusia, insomnia, constipation, and dry mouth

Metabolites 13 , 1006 (2023)