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These observations are in line with previous studies that reported beneficial effects of HR on the extensibility and elasticity of forearm skin [82] and facial skin [107]

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In consistent with previous results, the KKay prediabetic mice exhibit significant increases in serum and ileum levels of inflammatory factors such as IL-1, IL-6, LPS, NF-B, and TNF-, while liraglutide can reduce these inflammatory factors, suggesting an inhibitory effect of liraglutide on the bodys inflammatory response in prediabetic state