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Taking stomach acid-lowering drugs : Medications can block absorption, including antacids used to treat conditions like gastritis or esophageal reflux and antihistamines

Retatrutide also improved insulin sensitivity and glucose metabolism beyond what youd expect from weight loss alone, suggesting direct receptor-mediated effects on metabolic tissues

This is not a formal ceiling because no FDA-approved limit exists, but it represents the upper range of what is supported by preclinical scaling and provider experience

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