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Annual List Review Process Every year, WADA leads the revision process concerning the List, beginning with an initial meeting in January and concluding with the publication of the List by 1 October
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Specific activities have previously been reported for commercial enzyme preparations of GST M1-1 (3.7 mol min 1 mg 1 ), GST A1-1 (14.9 mol min 1 mg 1 ), and GST P1-1 (0.15 mol min 1 mg 1 ) at pH 6.5 and 25 C 8 , but later redetermined with somewhat altered conditions of pH 7.4 and 37 C to the higher values of 66.3, 126, and 1.36 mol min 1 mg 1 , respectively 17 The latter values are in general agreement with the values in Table 1 considering differences in reaction temperature and other conditions
Toxicology assessments in rats found no organ toxicity at doses up to 10 mg/kg (approximately 1000x the effective dose), no mutagenicity in Ames testing, and no teratogenic effects
