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Andrew had the below to say in this clip: Theres a fairly extensive literature on the fact that fadogia agrestis can be toxic to testicular cells and perhaps other cells when taken at very high dosages

Statin therapy is known to potentiate the effect of antihypertensive drugs [32, 33] through vasodilation, which is due to increased nitric oxide synthase activity [34], downregulation of angiotensin II-type 1 receptors [35], and endothelin-1 production [36]

The Am J of Physiol 276,1260272