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In the obese state, the abundance of intracellular nutrients activates mTORC1, which inhibits macrophage autophagy and leads to the accumulation of cellular waste, further exacerbating inflammation and metabolic dysregulation [197]

Therefore, for many patients, these benefits may outweigh any theoretical concerns about arrhythmias

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Measurement of early and late apoptosis using annexin V and PI flow cytometry We used FITC Annexin V Apoptosis Detection Kit with PI (BioLegend, San Diego, CA) to quantitate the early and late apoptosis of RINm5F cells