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In the medical and dermatological world, its main job is acting as a signaling molecule

Paiva I, Cellai L, Mriaux C, Poncelet L, Nebie O, Saliou J-M, et al

If results are promising, the programme moves to Phase 3: larger, global, randomised trials involving, dependent on the indication hundreds to sometimes even thousands of participants, designed to confirm efficacy and build a robust safety profile

Compared with other forms of cell death such as apoptosis, necrosis, and autophagy, ferroptosis exhibits distinct molecular mechanisms and biological features ( Table 1 ): (1) Iron Dependence: Ferroptosis is uniquely triggered by elevated intracellular iron levels, differentiating it from other cell death modes