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Dihexa(PNB-0408), an oligopeptide drug, is an orally active and blood-brain barrier-permeable analog of angiotensin IV

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The Phase 1 MAD study of oral VK2735 is an extension of the companys Phase 1 single ascending dose (SAD)/MAD trial of VK2735 administered subcutaneously mentioned above

The recommended dose of is 200 mg daily (100 mg bid), albeit increases in the dose up to 400 mg daily have been approved in cases in which the blood glucose-lowering effect is unsatisfactory [52]